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OS-01 Body Moisturizer on a bathroom shelf

Body lotion hydrates. It does not change the skin.

Hydration sits on top. The OS-01 peptide was measured on the skin itself, over twelve weeks.

Hydration sits on top. The OS-01 peptide was measured on the skin itself, over twelve weeks.

BODY MOISTURIZER

4.6
4.6 out of 5
4.6 out of 5
(3,885)

Nourishing hydration designed to strengthen crepey skin.4

Size: 250 mL / 8.45 fl oz

  • Age-Reversal Peptide
  • Smoothing
  • Firming
  • Fragrance Free
White bottle with black pump and 'One Skin' logo on a beige background
OS-01 BODY MOISTURIZER
OS-01 BODY MOISTURIZER BOTTLE and a black ONE SKIN logo, shown on a dark gray background with marketing text describing resilience, smoothness, and lightweight hydration.
A close-up of a person applying OS-01 BODY MOISTURIZER onto their thigh, with text overlay stating '41% increase in skin's barrier resilience after 12 weeks'.
Before-and-after skin texture comparison on an arm, with a beige panel at the bottom showing the text '70% reported visibly smoother texture' and a small citation note at the top.
A single OS-01 BODY MOISTURIZER cosmetic smear on a black background with text callouts reading CERAMIDES, SULFORAPHANE, and TREMELLA MUSHROOM.
A close-up of a petri dish filled with transparent gel, with text reading 'OS-01 PEPTIDE' and descriptive copy about reversing skin's visible biological age.
A white pump bottle of One Skin T3-C1 Body Tonic Supplement with a black pump dispenser, shown next to a customer review on a light gray grid background.
White bottle with black pump and 'One Skin' logo on a beige background
OS-01 BODY MOISTURIZER
OS-01 BODY MOISTURIZER BOTTLE and a black ONE SKIN logo, shown on a dark gray background with marketing text describing resilience, smoothness, and lightweight hydration.
A close-up of a person applying OS-01 BODY MOISTURIZER onto their thigh, with text overlay stating '41% increase in skin's barrier resilience after 12 weeks'.
Before-and-after skin texture comparison on an arm, with a beige panel at the bottom showing the text '70% reported visibly smoother texture' and a small citation note at the top.
A single OS-01 BODY MOISTURIZER cosmetic smear on a black background with text callouts reading CERAMIDES, SULFORAPHANE, and TREMELLA MUSHROOM.
A close-up of a petri dish filled with transparent gel, with text reading 'OS-01 PEPTIDE' and descriptive copy about reversing skin's visible biological age.
A white pump bottle of One Skin T3-C1 Body Tonic Supplement with a black pump dispenser, shown next to a customer review on a light gray grid background.
93%

reported improved skin hydration

70%

reported improved appearance

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  • Certified cruelty-free by The Leaping Bunny

  • Approved by the National
Eczema Association

  • Certified plastic neutral in partnership with RePurpose

  • Certified cruelty-free by The Leaping Bunny

  • Approved by the National
Eczema Association

  • Certified plastic neutral in partnership with RePurpose

  • Certified cruelty-free by The Leaping Bunny

  • Approved by the National
Eczema Association

  • Certified plastic neutral in partnership with RePurpose

Details
  • Our proprietary OS-01 Senescence-Blocking Peptide™ visibly slows cellular skin aging, resulting in skin that feels and acts younger over time
  • Boosts barrier strength while visibly smoothing skin, targeting a root cause of crepiness and sagging1
  • Clinically validated to strengthen the skin barrier by +41% in 12 weeks¹
  • Weightless texture absorbs quickly, delivering lightweight nourishing hydration with no residue
Clinical proof
  • +41% increase in skin's barrier resilience after 12 weeks¹
  • +38% increase in hydration after 12 weeks¹
  • 70% reported visibly smoother texture and improved general appearance¹

The Clinical Studies

Efficacy Study — Published in the Journal of Cosmetic Dermatology

A 12-week, double-blind, third-party clinical study evaluated the effects of OS-01 BODY MOISTURIZER on body skin hydration, barrier function, texture, and appearance. 60 participants were divided into two groups: one applied OS-01 BODY twice daily, while the other applied a placebo moisturizer twice daily. Hydration and trans-epidermal water loss (TEWL) were measured with instrumental devices (Corneometer and Tewameter). Participants also reported subjective improvements. Published in the Journal of Cosmetic Dermatology, Zonari et al., 2025.

The results after 12 weeks1:

  • 93% of participants reported improved skin hydration
  • +38% improvement in forearm and upper arm hydration (corneometer)
  • +41% improvement in skin barrier on forearm and +35% on upper arm (tewameter)
  • 70% reported improved skin texture
  • 70% reported improved overall appearance

Safety studies

OS-01 BODY MOISTURIZER is non-comedogenic, dermatologist tested, suitable for sensitive skin, fragrance free, and formulated without parabens, sulfates, phthalates, or other common irritants. Based on its formula and clinical testing, it has been awarded the National Eczema Association Seal of Acceptance™.

Our commitment to the scientific process

OneSkin products are validated with a rigorous process from the lab to the clinic: Lab testing on human skin to evaluate the effect on the cellular level, consumer testing with real users to ensure optimal texture and feel, and third-party clinical studies to evaluate the effect on the human level over time.
Ingredients

Formulated without
Our products are formulated without fragrance, parabens, sulfates, lanolin, MCI/MI, DEA, heavy metals, talc, petrolatum/paraffin/mineral oil, gluten, phthalates, and PFAs. We also avoid unnecessary emulsifiers, preservatives, and solvents.

Ingredients
Water (Aqua), Glycerin, Limnanthes Alba (Meadowfoam) Seed Oil, Sorbitan Olivate, Squalane, Avena Sativa (Oat) Kernel Oil, Prunus Domestica Seed Oil, Cetearyl Olivate, Mangifera Indica (Mango) Seed Butter, Saccharide Isomerate, Panthenol, Tremella Fuciformis Sporocarp Extract, Tocopheryl Acetate, Decapeptide-52*, Allantoin, Asiaticoside, Centella Asiatica Extract, Sodium Hyaluronate Crosspolymer, Ceramide NG, Galactoarabinan, Lepidium Sativum Sprout Extract, Soy Isoflavones, Niacinamide, Betaine, Bentonite, Cetyl Palmitate, Sorbitan Palmitate, Lecithin, Xanthan Gum, Polyglyceryl-10 Laurate, Polyglyceryl-6 Oleate, Sorbitan Oleate, Glyceryl Caprylate, Polysorbate 80, Alcohol, Caprylyl Glycol, Sorbic Acid, Caprylhydroxamic Acid, Tetrasodium Glutamate Diacetate, Phenoxyethanol. *OS-01 Peptide

How to use

Apply to arms, legs, chest, back, and stomach and massage until absorbed. Use 2x daily.

Complete the Protocol

A first-of-its-kind body moisturizer for whole-body health and longevity.

Abstract icon of an hour glass with a 3/4 circle around it

Powered by the
OS-01 Peptide™

Proven to reverse skin's visible biological age by reversing the visible effects of senescent (dysfunctional, aging) cells.

Abstract icon of a shield with dots and and 3 circles in the middle

Supports skin's resilience

Strengthens skin's barrier, addressing a root cause of skin thinning, visible sagging, and crepiness for firmer-looking body skin.

Abstract icon showing 3 lines and an arrow pointing up

Visibly smooths

Supports skin health at the cellular level for skin that looks, feels, and acts younger.

Icon depicting a drop of water hitting a surface

Lightweight hydration

Absorbs quickly, delivering nourishing hydration with no residue.

Abstract icon of an hour glass with a 3/4 circle around it

Powered by the
OS-01 Peptide™

Proven to reverse skin's visible biological age by reversing the visible effects of senescent (dysfunctional, aging) cells.

Abstract icon of a shield with dots and and 3 circles in the middle

Supports skin's resilience

Strengthens skin's barrier, addressing a root cause of skin thinning, visible sagging, and crepiness for firmer-looking body skin.

Abstract icon showing 3 lines and an arrow pointing up

Visibly smooths

Supports skin health at the cellular level for skin that looks, feels, and acts younger.

Icon depicting a drop of water hitting a surface

Lightweight hydration

Absorbs quickly, delivering nourishing hydration with no residue.

OS-01 Peptide logo featuring a solid orange square on the left, followed by the text 'OS-01' in black and 'PEPTIDE' in bold black letters, with a small trademark symbol.

Engineered to reverse skin’s visible biological age.2

Built on over a decade of longevity science, our proprietary OS-01 Peptide™ reverses the visible effects of senescent (dysfunctional) cells that degrade collagen, elastin, hyaluronic acid and barrier strength. The result: skin that looks, feels, and acts younger over time.

Explore the science →
The difference

Most body lotions were never measured on anything but comfort.

Comfort lasts an hour. OneSkin ran a twelve-week study on human skin and measured hydration, texture and appearance as endpoints, not as claims.

Clinically validated results that build over time

A side-by-side before and after comparison of a human leg showing skin improvement over 12 weeks. The left panel is labeled BEFORE and shows sun-damaged, reddish, scaly skin with a circled area highlighting the condition.

70%

reported improved appearance after 12 weeks1

A side-by-side before and after comparison of an elbow showing skin texture and hyperpigmentation improvement over 12 weeks. The left panel is labeled 'BEFORE' with a black square icon, and the right panel is labeled 'AFTER 12 WEEKS' with a red square icon.

70%

of users reported smoother looking skin after 12 weeks1

A side-by-side before and after comparison of a human leg, showing a dramatic reduction in dry, cracked, and bubbly skin on the left and smoother, healthier skin on the right.

93%

reported improved hydration after 12 weeks1

Week 1

Hydration you can feel

  • OS-01 Peptide™ begins working on contact
  • Lightweight, fast-absorbing texture
  • Instant softness and hydration
Week 4

Noticeably smoother, more hydrated skin

  • 71% reported better hydration¹
  • 68% reported improved texture¹
  • Skin feels more even and comforted
Week 12

Stronger skin, stronger body

  • +41% increase in barrier strength¹
  • Your largest organ, fortified for healthy aging

The clinical studies

Measured on real skin, not modelled.

93%
reported improved skin hydration
70%
reported improved appearance after 12 weeks
70%
reported visibly smoother texture
68%
reported improved texture

Key ingredients

A single irregular, smooth, off-white to light gray solid piece with a glossy surface, centered on a solid black background.
OS-01 Peptide™

Proven to reverse skin's visible biological age by reversing the visible effects of senescent (dysfunctional, aging) cells.

Tremella fuciformis mushroom extract

Retains up to 400x more water than common humectants to attract and hold hydration.

Ceramides

Support skin’s natural lipid barrier to protect, boost moisture retention, and visibly repair dry and sensitive skin.

Sulforaphane

A powerful antioxidant found in lepidium sativum sprout extract known to protect skin against the visible effects of environmental stressors and oxidative damage.

Saccharide isomerate

A plant-derived moisture magnet that binds to skin for up to 72 hours of hydration support.

All Ingredients

Formulated without
Our products are formulated without fragrance, parabens, sulfates, lanolin, MCI/MI, DEA, heavy metals, talc, petrolatum/paraffin/mineral oil, gluten, phthalates, and PFAs. We also avoid unnecessary emulsifiers, preservatives, and solvents.

Ingredients
Water (Aqua), Glycerin, Limnanthes Alba (Meadowfoam) Seed Oil, Sorbitan Olivate, Squalane, Avena Sativa (Oat) Kernel Oil, Prunus Domestica Seed Oil, Cetearyl Olivate, Mangifera Indica (Mango) Seed Butter, Saccharide Isomerate, Panthenol, Tremella Fuciformis Sporocarp Extract, Tocopheryl Acetate, Decapeptide-52*, Allantoin, Asiaticoside, Centella Asiatica Extract, Sodium Hyaluronate Crosspolymer, Ceramide NG, Galactoarabinan, Lepidium Sativum Sprout Extract, Soy Isoflavones, Niacinamide, Betaine, Bentonite, Cetyl Palmitate, Sorbitan Palmitate, Lecithin, Xanthan Gum, Polyglyceryl-10 Laurate, Polyglyceryl-6 Oleate, Sorbitan Oleate, Glyceryl Caprylate, Polysorbate 80, Alcohol, Caprylyl Glycol, Sorbic Acid, Caprylhydroxamic Acid, Tetrasodium Glutamate Diacetate, Phenoxyethanol. *OS-01 Peptide

Why subscribe

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A free gift on your first order

Travel-size OS-01 EYE CREAM with your first subscription.

OneSkin Longevity Protocol

OS-01 BODY MOISTURIZER

Write a Review (Opens in a new window)
3,885 reviews
  • C
    Cindie
    Reviewing
    OS-01 BODY MOISTURIZER
    I recommend this product
    Rated 5 out of 5 stars
    4 minutes ago
    5 Stars

    I like the texture and scent of it. Not greasy at all

    Was this helpful?
  • KB
    Kirsten B.
    Verified Reviewer
    Reviewing
    OS-01 BODY MOISTURIZER
    I do not recommend this product
    Rated 1 out of 5 stars
    Yesterday
    No improvements in skin texture

    I wanted this lotion to work so badly. Been using twice daily for months; the bottle is almost empty. I saw no improvement in crepey skin on legs. Not going to repurchase sadly.

    Was this helpful?
    OneSkin
    Yesterday

    Hi Kirsten,

    Thank you for taking the time to share your feedback about OS-01 BODY MOISTURIZER — we really appreciate your honesty.

    I'm genuinely sorry to hear that you didn't see the improvements in your skin texture that you were hoping for, especially after using it consistently for months. We understand how disappointing that must be, and we're sorry the product didn't meet your expectations.

    Your feedback is really valuable to us, and we'd love to understand more about your experience so we can continue to improve. If you'd like to discuss what you've been experiencing further, our support team would be happy to hear from you at support@oneskin.co.

    Thank you for giving OneSkin a try, and we're sorry you didn't have the experience you were hoping for.

  • RP
    Roe P.
    Verified Buyer
    Reviewing
    OS-01 BODY MOISTURIZER
    I recommend this product
    Rated 5 out of 5 stars
    2 days ago
    Moisturizer

    So far i'm satisfied with the moisturizer. It is lightweight and doesn't feel greasy.

    Was this helpful?
  • S
    S
    Reviewing
    OS-01 BODY MOISTURIZER
    Rated 3 out of 5 stars
    2 days ago
    3 Stars

    Not sure if it’s working or not but maybe I have to finish the bottle first.

    Was this helpful?
  • SE
    suzanne e.
    Verified Buyer
    Reviewing
    OS-01 BODY MOISTURIZER
    I recommend this product
    Rated 5 out of 5 stars
    3 days ago
    Love This Moisturizer

    I thought this was pricey for body moisturizer but when my best friend started raving about how soft her skin was I had to try it. She was right! I’m hooked. The look and texture of my skin has really improved. Worth the money in my opinion.

    Was this helpful?
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Frequently Asked Questions

How do I change, skip or cancel my subscription?

Anytime, from your account.

What if it does not work for me?

Try it risk-free for 30 days. See our refund policy for details.

What makes OS-01 BODY MOISTURIZER different from a standard body lotion?

While the formula contains a targeted blend of hydrating, barrier-supporting, and antioxidant ingredients that will instantly hydrate and comfort skin, the core difference lies with the proprietary OS-01 Peptide™.

 

The OS-01 Peptide™ was scientifically engineered by longevity scientists to reverse the visible signs of senescence, including barrier weakening and thinning, so skin will look and feel younger and healthier over time. Because of the OS-01 Peptide™, OS-01 BODY MOISTURIZER addresses a root cause of crepey, thinning skin and supports the health of your largest organ, making this product so much more than a regular moisturizer.

Can I use OS-01 BODY MOISTURIZER on my face?

Some customers in drier climates or with dry skin have reported that they use OS-01 BODY MOISTURIZER on their face. That said, OS-01 BODY MOISTURIZER was formulated for body skin—with active ingredients and nourishing oils suited to thicker skin. For most customers, OS-01 FACE MOISTURIZER or OS-01 EYE CREAM is more suitable for facial skin.

How do I use it?

To fortify your largest organ and body's first line of defense (your skin), we recommend applying it to your entire body daily. For targeted results, you can apply to specific areas of skin.

How long will one bottle last?

The 250 ml bottle lasts approximately 1–2 months when used as directed.

How should I store it, and what's the shelf life?

OS-01 BODY MOISTURIZER has a 24-month shelf life. Store at room temperature, away from direct sunlight.

OS-01 BODY MOISTURIZER

Body lotion hydrates. It does not change the skin.

Subscribe and save 15%. Change, skip or cancel anytime.

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Citations

  1. Based on a double-blind, third-party 12-week clinical study with 27 participants aged 62–82. (Zonari, A., et al. Journal of Cosmetic Dermatology, 2025.)
  2. Visible biological age defined as signs of aging such as smoothness and barrier strength. Based on a double-blind, third-party 12-week clinical study with 22 participants aged 54–65. (Zonari, A., et al. Journal of Cosmetic Dermatology, 2024.)